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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and exercising.



Using two separate drugs to lose weight can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you ought to err assisting caution and let the FDA do its job and demand some research be done in order that the public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on the medications.



Researchers found out that participants taking this drug for any year, lost weight within four weeks and have kept the extra weight off during the entire 56 weeks of the study. Contrave is often a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of more than one active ingredient, which can make them more efficient and safer.



Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA.



Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug could also raise blood pressure and heart rate, and must not be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.



The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure, as well as by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients on the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.





"This is the first drug I'm aware of that targets the two appetite and reward centres inside the brain," he said.
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